Kuhl Lassen Award lecture - Cholinergic Imaging - New Insights from Multimodal Approaches
Sponsored by the Brain Imaging Council
Karina Mosci, MD, Hospita Das Forcas Armadas (HFA)
Karina Mosci, MD
Nicolaas Bohnen, MD, Phd, University of Michigan - Ann Arbor
The main purpose of the lecture is to summarize the current state of cholinergic in vivo imaging in neurodegeneration with intended audience of nuclear medicine physicians, radiochemists and physicists interested in molecular neuroimaging in neurodegeneration.
Recent advances in neuroimaging show that cholinergic hypothesis is evolving from a primary focus on memory toward a more complex system interacting with other neurodegenerations in neurodegenerative disorders. Unlike Alzheimer's disease, cholinergic system changes involve not only cortical top-down cognitive control but also subcortical salience functions in Parkinson's disease. Cholinergic-dopaminergic interactions may aggravate executive function deficits jointly increasing the risk of conversion to dementia in Parkinson's disease or dementia with Lewy bodies. Cortical cholinergic losses in neurodegeneration are not diffuse but have topographic vulnerability that overlap with important hubs of neural networks involved in various cognitive functions. Bidirectional changes in regional cerebral cholinergic receptor expression may reflect the effects of neural function losses in some regions and compensatory responses in other brain areas. Cholinergic adaptation to neurodegenerative injury is emerging as a novel research target.
1. Learn about the role of cholinergic system changes in dementia and Lewy body parkinsonism.
2. Describe interactions of the cholinergic system with dopaminergic, beta-amyloid, functional and microstructural changes in the brain.
3. Discuss how cholinergic network changes may play a role in specific clinical symptoms.
CE Credit applications for physicians, pharmacists, physicists and technologists are pending. Check back for updates regarding CE Credit status.